Annual Change in Insulin Sensitivity

F. Isken; U. Abraham; M. O. Weickert; F. Keyhani-Nejad; A. M. Arafat; J. Spranger; A.F. H. Pfeiffer; M. Möhlig

doi:10.1055/s-0031-1286310

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2011; 43(10): 720-722
DOI: 10.1055/s-0031-1286310

Humans, Clinical

Georg Thieme Verlag KG Stuttgart · New York

Annual Change in Insulin Sensitivity

F. Isken

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

^†Deceased

,

U. Abraham

³Laboratory of Chronobiology, Department of Medical Immunology, Charité-University-Medicine Berlin, Berlin, Germany

,

M. O. Weickert

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

⁴Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, UK and Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, UK

,

F. Keyhani-Nejad

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

,

A. M. Arafat

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

,

J. Spranger

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

,

A.F. H. Pfeiffer

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

,

M. Möhlig

¹Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany

²Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Berlin, Germany

› Author Affiliations

Abstract

The incidence of both type 2 diabetes and cardiac events is reported to be higher during winter, indicating a putative annual periodic change in insulin sensitivity (IS). Annual differences in IS – quantified as HOMA-%S and Matsuda-Sensitivity Index – were analyzed using a cosine wave-fitting algorithm in a cross-sectional study group including 2 385 participants. Additionally, semi-annual differences in IS were compared. We found periodicity for HOMA-%S and Matsuda-Sensitivity Index (p=0.02 or 0.006), which was strengthened after restriction to participants without diabetes (p=0.009 or 0.004). The rhythm amplitude of 0.08 indicated moderate changes in IS throughout the year. IS was significantly higher when participants were enrolled during the second vs. the first half of the year (HOMA-%S 112.0±3.0% vs. 97.4±2.4%, p<0.001). The impact of the half-year on IS, which remained significant after adjustment for confounders, was again moderate and explained only 0.5% of the variation. IS showed a significant moderate annual periodicity, which may affect the interpretation of studies reporting small changes in IS.

Key words

insulin resistance - insulin sensitivity - annual - HOMA

Full Text

References

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